Polymorphisms in xenobiotic metabolism-related genes in patients with hepatocellular carcinoma: a case–control study

This study was performed to investigate the relationship between polymorphisms in microsomal epoxide hydrolase (mEH; Tyr113His and His139Arg substitution) glutathione S-transferase (GST; GSTM1 deletion, GSTT1 GSTP1.Ala114Val their correlation with clinico-histopathological features hepatocellular carcinoma (HCC).We evaluated environmental risk factors genetic alterations 556 individuals (86 cases 470 controls). PCR multiplex for GSTT1, polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) GSTP1, real-time mEH were performed. Statistical analyses using multiple logistic regression tests.Age over 48 years (p < 0.001) alcohol consumption = 0.021) predictors of increased developing HCC. all models 0.05), except recessive model, null genotype (odds ratio [OR] 0.43, 95% confidence interval [CI] 0.21–0.87, p 0.019) an Polymorphic GSTM1, GSTP1.Ala114Val, mEH.His139Arg wild-type mEH.Tyr113His (OR 5.04; CI 1.59–16.04; 0.006) associated HCC.Age years, consumption, presence polymorphic variants GSTP1